一項有安慰劑的研究發現，Omega-3 脂肪酸 EPA 可以改善停經婦女 熱潮紅及沮喪的現象。研究中的婦女服用 1.05 克的  ethyl EPA 及 0.15 克的 ethyl DHA

Lucas M, Asselin G, Mérette C, Poulin MJ, Dodin S. Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial. Am J Clin Nutr. 2009 Feb;89(2):641-51.

Lucas M, Asselin G, Mérette C, Poulin MJ, Dodin S. Effects of ethyl-eicosapentaenoic acid omega-3 fatty acid supplementation on hot flashes and quality of life among middle-aged women: a double-blind, placebo-controlled, randomized clinical trial. Menopause. To be published in print March 2009;16(2). Published Online ahead of print 2008 Nov 20.