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N-acetyl-cysteine (NAC) 減少流行性感冒的肺部發炎

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1subject: N-acetyl-cysteine (NAC) 減少流行性感冒的肺部發炎Promote 0 Bookmark 02009-11-20quote  

最近新流感 H1N1 有點盛行,感冒引起的肺炎常是造成死亡原因之一。

N-acetyl-cysteine (NAC) 乙醯基半胱氨酸,是由人體必須的胺基酸 L-cysteine 加上 acetyl 乙醯,以增加 L-cysteine 穩定度。

NAC 可以幫助體內抗氧化劑-麩胱甘肽glutathione的合成,減少一氧化氮 nitric oxide 的發炎反應。一氧化氮是氣喘、emphysema 肺氣腫、cystic fibrosis 囊性纖維變性 的發炎標記。NAC 也可以減少活性氧化類 reactive oxygen species, 發炎inflammatory cytokines 及致命的 NADPH oxidase。 NAC 可以調控免疫反應,增強殺病菌的 T-cells 的繁殖。

在老鼠的實驗中,NAC 可以大幅減少感染流行性感冒的老鼠的死亡率。NAC 也常被用來稀釋痰液,讓痰容易咳出。

價格約 250*600mg / US$23.4

 References:

1. Bengtsson A, Lundberg M, Avila-Carino J, et al. Thiols decrease cytokine levels and down-regulate the expression of CD30 on human attergen-specific T helper (Th) 0 and Th2 cells. Clin Exp Immunol. 2001 Mar; 123(3):350-60.

2. McCarty MF, Barroso-Aranda J, Contreras F. Practical strategies for targeting NF-kappaB and NADPH oxidase may improve survival during lethal influenza epidemics. Med Hypotheses. 2009 Jun 30. Published Online Ahead of Print.

3. Ungheri D, Pisani C, Sanson G, et al. Protective effect of n-acetylcysteine in a model of influenza infection in mice. Int J Immunopathol Pharmacol. 2000 Sep-Dec;13(3):123-8.

4. Hadzic T, Li L, Cheng N, et al. The role of low molecular weight thiols in T lymphocyte proliferation and IL-2 secretion. J Immunol. 2005 Dec 15;175(12):7965-72.

5. Fraternale A, Paoletti MF, Casabianca A, et al. Antiviral and immunomodulatory properties of new pro-glutathione (GSH) molecules. Curr Med Chem. 2006;13(15):1749-55.

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